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“Self-cleaning” Membranes for Glucose Biosensors

“Self-cleaning” Membranes for Glucose Biosensors

Glucose biosensors or “continuous glucose monitors (CGMs)” that would continuously monitor blood sugar levels (from the interstitial fluid) have advanced diabetes management beyond that afforded by conventional finger prick tests. However, on-the-market CGMs have a high user burden associated with their limited lifetime and the need for a transcutaneous design to enable frequent exchanges. The lifetime of current and emergent CGMs are limited by “biofouling” – surface adsorption of proteins and cells (part of the foreign body response) – which quickly blocks glucose diffusion.

What we are doing

We are developing a “self-cleaning membrane” using thermoresponsive hydrogels that undergo cyclical and subtle deswelling/reswelling to “clean off” proteins and cells in order to maintain glucose diffusion and extend biosensor lifetime.

“Self-cleaning” Membranes for Glucose Biosensors

Related Publications

Silicone-containing thermoresponsive membranes to form an optical glucose biosensor

Dong, P.; Singh, K.A.; Soltes, A.M.; Ko, B.K.; Gahararwar, A.K.; McShane, M.J.; Grunlan, M.A. “Silicone-containing thermoresponsive membranes to form an optical glucose biosensor,” J. Mater. Chem. B, 2022, 10, 6118-6132

[DOI]

A glucose biosensor based on phosphorescence lifetime sensing and a thermoresponsive membrane

Dong, P.; Ko, B.K.; Lomeli, K.A.; Clark, E.C.; McShane, M.J.; Grunlan, M.A. “A glucose biosensor based on phosphorescence lifetime sensing and a thermoresponsive membrane,” Macromol. Rapid Comm., 2022, 2100902

[DOI]

A comb architecture to control the selective diffusivity of a double network hydrogel

Dong, P.; Schott, B.J.; Means, A.K.; Grunlan, M.A. “A comb architecture to control the selective diffusivity of a double network hydrogel,” ACS Appl. Polym. Mater. 2020, 2, 5269–5277

[DOI]

A self-cleaning, mechanically robust membrane for minimizing the foreign body reaction: towards extending the lifetime of sub-Q glucose biosensors

Means, A.K.; Dong, P.; Clubb, Jr, F.J.; Friedemann, M.C.; Colvin, L.E.; Shrode, C.A.; Coté, G.L; Grunlan, M.A. “A self-cleaning, mechanically robust membrane for minimizing the foreign body reaction: towards extending the lifetime of sub-Q glucose biosensors,” J. Mater. Sci. Mater. Med. 2019, 30, 79

[DOI]

A layer-by-layer (LbL) approach to retain an optical glucose sensing assay within the cavity of a hydrogel membrane

Locke, A.K.; Means, A.K.; Dong, P.; Nichols, T.J.; Coté, G.L.; Grunlan, M.A. “A layer-by-layer (LbL) approach to retain an optical glucose sensing assay within the cavity of a hydrogel membrane,” ACS Applied Bio Mater., 2018, 1, 1319-1327

[DOI]

Foreign body reaction to a subcutaneously implanted self-cleaning, thermoresponsive hydrogel membrane for implanted glucose biosensors

Abraham, A.A.; Means, A.K.; Clubb, Jr, F.J.; Fei, R.; Locke, A.K.; Gacasan, E.G.; Coté, G.L; Grunlan, M.A. “Foreign body reaction to a subcutaneously implanted self-cleaning, thermoresponsive hydrogel membrane for implanted glucose biosensors,” ACS Biomater. Sci. Eng., 2018, 4, 4104-4111

[DOI]

Self-cleaning, thermoresponsive P(NIPAAm-co-AMPS) double network membranes for implanted glucose biosensors

Fei, R., Means, A.K., Abraham, A.A.; Locked, A.K.; Coté; G.L.; Grunlan, M.A.. “Self-cleaning, thermoresponsive P(NIPAAm-co-AMPS) double network membranes for implanted glucose biosensors,” Macromol. Mater. Eng., 2016, 301, 935-943

[DOI]

Thermoresponsive double network micropillared hydrogels for cell release

Fei, R.; Hou, H.; Munoz-Pinto, D.; Han, A.; Hahn, M.S.; Grunlan, M.A. “Thermoresponsive double network micropillared hydrogels for cell release” Macromol. Biosci.; 2014, 14, 1346-1352

[DOI]

Thermoresponsive nanocomposite hydrogels: Transparency, rapid deswelling and cell release

Hou, Y.; Fei, R.; Burkes, J.C.; Lee, S.D., Munoz-Pinto, D.; Hahn, M.S.; Grunlan, M.A. “Thermoresponsive nanocomposite hydrogels: Transparency, rapid deswelling and cell release,” J. Biomat. Tissue Eng. 2011, 1, 93-100.

A self-cleaning membrane to extend the lifetime of an implanted glucose biosensor

Abraham, A.A.; Fei, R.; Coté, G.L.; Grunlan, M.A. “A self-cleaning membrane to extend the lifetime of an implanted glucose biosensor,” ACS Appl. Mater. & Interfaces, 2013, 5, 12832-12838

[DOI]

Thermoresponsive nanocomposite double network nanocomposite hydrogels

Fei, R.; George, J.T.; Park, J., Grunlan, M.A. “Thermoresponsive nanocomposite double network nanocomposite hydrogels,” Soft Matter 2012, 8, 481-487

[DOI]

Micropatterning of poly(N-isopropylacrylamide) PNIPAAm hydrogels: Effects of thermosensitivity and cell release behavior

Hou, H.; Hou, Y.; Grunlan, M.A.; Munoz-Pinto, D.J.; Hahn, M.S.; Han, A. “Micropatterning of poly(N-isopropylacrylamide) PNIPAAm hydrogels: Effects of thermosensitivity and cell release behavior,” Sensors and Material, 2010, 22, 109-120

[DOI]

A thermoresponsive hydrogel poly(N-isopropylacrylamide) micropatterning method using microfluidics techniques

Hou, H.; Kim, W.; Grunlan, M.; Han, A. “A thermoresponsive hydrogel poly(N-isopropylacrylamide) micropatterning method using microfluidics techniques,” J. Micromech. Microeng. 2009, 19, 127001-127007

[DOI]

Development of a self-cleaning sensor membrane for implantable biosensors

Gant, R.; Hou, Y.; Grunlan, M.A., Coté, G.L. “Development of a self-cleaning sensor membrane for implantable biosensors,” J. Biomed. Mater. Res. 2009, 90A, 695-701

[DOI]

Thermoresponsive nanocomposite hydrogels with cell-releasing behavior

Hou, Y.; Matthews, A.R.; Smitherman, A.M.; Bulick, A.S.; Hahn, M.S.; Hou, H.; Han, A.; Grunlan, M.A. “Thermoresponsive nanocomposite hydrogels with cell-releasing behavior,” Biomaterials 2008, 29, 3175-3184

[DOI]