“Self-cleaning” Membranes for Glucose Biosensors

Glucose biosensors or “continuous glucose monitors (CGMs)” that would continuously monitor blood sugar levels (from the interstitial fluid) have advanced diabetes management beyond that afforded by conventional finger prick tests. However, on-the-market CGMs have a high user burden associated with their limited lifetime and the need for a transcutaneous design to enable frequent exchanges. The lifetime of current and emergent CGMs are limited by “biofouling” – surface adsorption of proteins and cells (part of the foreign body response) – which quickly blocks glucose diffusion.

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