Preventing clotting and infection on device surfaces
A variety of medical devices are made from silicones and polyurethanes, but these rapidly adsorb proteins, and cells, often leading to clotting and infection.
What we are doing
Our research is directed at developing coating technologies to prevent protein adsorption and subsequent negative events on medical devices, including reducing clotting and infection, as well as enabling pumpless flow of blood in microfluidic point-of-care devices. Towards this goal, we have developed “PEO-silane amphiphiles” as surface modifying additives (SMAs) for silicones and polyurethane devices.
Related Publications
Non-toxic, anti-fouling silicones with variable PEO-silane amphiphiles content
Fay, F.; Hawkins, M.L.; Réhel, K.; Grunlan, M.A.; Linossier, I. “Non-toxic, anti-fouling silicones with variable PEO-silane amphiphiles content,” Green Mater., 2016, 4, 53-62
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