Preventing clotting and infection on device surfaces
A variety of medical devices are made from silicones and polyurethanes, but these rapidly adsorb proteins, and cells, often leading to clotting and infection.
What we are doing
Our research is directed at developing coating technologies to prevent protein adsorption and subsequent negative events on medical devices, including reducing clotting and infection, as well as enabling pumpless flow of blood in microfluidic point-of-care devices. Towards this goal, we have developed “PEO-silane amphiphiles” as surface modifying additives (SMAs) for silicones and polyurethane devices.
Related Publications
Siloxane-tethered poly(2-ethyl-2-oxazoline) as surface modifying additives for anti-fouling silicones
Negrón Hernández, J.; Palacharla, A.S.; Kanu, D.K.; Stafslien, S.J.; Vander Wal, L.; Grunlan, M.A. “Siloxane-tethered poly(2-ethyl-2-oxazoline) as surface modifying additives for anti-fouling silicones,” Eur. Polym. J., 2026, 249, 114638.
[DOI]
Biomedical silicones: Leveraging additive strategies to propel modern utility
Marmo, A.C.; Grunlan, M.A. “Biomedical silicones: Leveraging additive strategies to propel modern utility,” ACS Macro Lett. 2023, 12, 177-182
[DOI]
Amphiphilic silicones for the facile dispersion of carbon nanotubes and formation of soft skin electrodes
Marmo, A.C.; Lott, L.R.; Pickett, J.H.; Koller, H.E.; Nitschke, B.M.; Grunlan, M.A. Amphiphilic silicones for the facile dispersion of carbon nanotubes and formation of soft skin electrodes,” ACS Appl. Polym. Mater. 2023, 5, 775-783
[DOI]
Characterizing the separation behavior of photocurable PDMS on a hydrogel film during VAT photopolymerization: A benchmark study
Yang, F.; Kazi, A.; Marmo, A.C.; Grunlan, M.A.; Tai, B.L. “Characterizing the separation behavior of photocurable PDMS on a hydrogel film during VAT photopolymerization: A benchmark study,” Additive Manuf. 2022, 58, 103070
[DOI]
Amphiphilic silicones to mitigate lens epithelial cell growth onto intraocular lenses
Marmo, A.C.; Rodriguez Cruz, J.J.; Pickett, J.H.; Lott, L.R.; Theibert, D.S.; Chandler, H.; Grunlan, M.A. “Amphiphilic silicones to mitigate lens epithelial cell growth onto intraocular lenses,” J. Mater. Chem. B, 2022, 10, 3064-3072
[DOI]
A thin whole blood smear prepared via a pumpless microfluidic
Dogbevi, K.S.; Ngo, B.K.D.; Branan, K.L.; Gibbens, A.M.; Grunlan, M.A.; Coté, G.L. “A thin whole blood smear prepared via a pumpless microfluidic,” Microfluid. Nanofluid., 2021, 25, 59
[DOI]
Brightfield and fluorescence in-channel staining of thin blood smears generated in pumpless microfluidic
Dogbevi, K.S.; Ngo, B.K.D.; Branan, K.L.; Gibbens, A.M.; Grunlan, M.A.; Coté, G.L. “Brightfield and fluorescence in-channel staining of thin blood smears generated in pumpless microfluidic,” Anal. Methods, 2021, 13, 2238-2247
[DOI]
Amphiphilic, thixotropic additives for extrusion-based 3D printing of silica-reinforced silicone
Suriboot, J.; Marmo, A.C.; Ngo, B.K.D.; Nigam, A.; Ortiz-Acosta, D.; Tai, B.L.; Grunlan, M.A. “Amphiphilic, thixotropic additives for extrusion-based 3D printing of silica-reinforced silicone,” Soft Matter, 2021, 17, 4133-4142
[DOI]
Amphiphilic silicones to reduce the absorption of small hydrophobic molecules
Quiñones-Pérez, M.; Cieza, R.; Ngo, B.K.D.; Grunlan, M.A.; Domenech, M. “Amphiphilic silicones to reduce the absorption of small hydrophobic molecules,” Acta Biomaterialia, 2021, 121, 339-348
[DOI]
Thromboresistance of polyurethanes modified with PEO-silane amphiphiles
Ngo, B.K.D.; Lim, K.K.; Johnson, J.C.; Jain, A.; Grunlan, M.A. “Thromboresistance of polyurethanes modified with PEO-silane amphiphiles,” Macromol. Biosci. 2020, 2000193
[DOI]
Mechanical isotropy and post-cure shrinkage of polydimethylsiloxane printed with digital light processing
Kim, D.S.; Suriboot, J.; Grunlan, M.A.; Tai, B.L. “Mechanical isotropy and post-cure shrinkage of polydimethylsiloxane printed with digital light processing,” Rapid Prototyping J. 2020, 26, 1447-1452
[DOI]
Pumpless, ‘self-driven’ microfluidic channels with controlled blood flow using an amphiphilic silicone
Dogbevi, K.S.; Ngo, B.K.D.; Blake, C.W.; Grunlan, M.A.; Coté, G.L. “Pumpless, ‘self-driven’ microfluidic channels with controlled blood flow using an amphiphilic silicone,” ACS Appl. Polymer. Mater. 2020, 2, 1731-1738
[DOI]
Thromboresistance of silicones modified with PEO-silane amphiphiles
Ngo, B.K.D.* Barry, M.E.; Lim, K.K.; Johnson, J.C.; Luna, D.J.; Pandian, N.K.R.; Jain, A.; Grunlan, M.A. “Thromboresistance of silicones modified with PEO-silane amphiphiles,” ACS Biomater. Sci. Eng., 2020, 6, 2029-2037
[DOI]
Feasibility study of silicone stereolithography with an optically created dead zone
Kim, D.S.; Suriboot, J.; Grunlan, M.A.; Tai, B.L. “Silicone 3D printing with an optically created dead zone,” Addit. Manuf., 2019, 29, 100793
[DOI]
Protein resistant polymeric biomaterials
Ngo, B.K.D.; Grunlan, M.A. “Protein resistant polymeric biomaterials,” ACS Macro Lett., 2017, 6, 992-1000
[DOI]